Paks: Should I put lots of Paks (or other PP directives into one GPO?)

First, please read this FAQ entry Here

Then, as a suggestion, the best practice for PolicyPak is to have one GPO for each “thing” you want to do.

For instance, if you wanted to manage Chrome, you could create ONE GPO and then use Item Level Targeting to specify the conditions
of WHO would get the settings WHEN. Here is an example:

Application Manager Screenshot

Then you would do the same for another GPO, say, for Firefox, and another GPO for Internet Explorer settings, and so on.